# Cutaneous Phenomics and Transcriptomics

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2024 · $255,663

## Abstract

PROJECT SUMMARY
The Cutaneous Phenomics and Transcriptomics Core (CPAT) of the Penn Skin Biology and Diseases
Resource-based Center (SBDRC) furthers the NIAMS mission by providing a broad array of valuable services
enabling investigators to define the cutaneous phenotype, genotype and transcriptome of their cutaneous
experimental models. CPAT provides unparalleled expertise in highly utilized services ranging from tissue
processing and tissue immunohistochemistry/immunofluorescence to mRNA in situ hybridization and access to
millions of archived skin samples and expert skin histology consultations. Excitingly, CPAT now offers an
innovative collection of sophisticated experimental approaches for analyzing skin samples including laser-
capture microdissection of skin samples coupled with RNA or whole-exome sequencing, single-cell RNA
sequencing, in vivo two-photon and macrofluorescence imaging of skin, and multiple sophisticated assays to
evaluate skin barrier function. Together, these synergistic services enable investigators to rigorously
interrogate their experimental model and answer critical outstanding questions within skin biology and disease.
CPAT has assembled a talented and experienced team to provide its members with the highest level of quality
across its services. CPAT faculty and staff possess extensive expertise in providing all of these services and
this experience, coupled with the outstanding environment in Penn Dermatology, will provide innovative and
robust results to investigators evaluating hypotheses in cutaneous biology. Together, CPAT provides an
economy of scale across its services that conserves the financial resources of users thereby furthering the
research of members and will promote new collaborations between investigators in the field of cutaneous
biology. In summary, CPAT services will drive new discoveries in cutaneous biology and disease and create
new knowledge to identify novel disease biomarkers and therapeutic targets.

## Key facts

- **NIH application ID:** 10889042
- **Project number:** 5P30AR069589-09
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** John T. Seykora
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $255,663
- **Award type:** 5
- **Project period:** 2016-09-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10889042

## Citation

> US National Institutes of Health, RePORTER application 10889042, Cutaneous Phenomics and Transcriptomics (5P30AR069589-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10889042. Licensed CC0.

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