# Biomedical Data Science Core (BDSC)

> **NIH NIH P30** · UNIVERSITY OF PENNSYLVANIA · 2024 · $146,250

## Abstract

PROJECT SUMMARY (BDSC)
The “Biomedical Data Science Core” (BDSC) was founded on July 1, 2020 in response to growing need for
expertise in advanced biostatistics, bioinformatics and human subject research design to support the expanding
portfolio of human and translational research being conducted by members of the Center for Molecular Studies
in Digestive and Liver Diseases (CMSDLD). BDSC is the Clinical Core for CMSDLD. Prior to this time, some of
the services related to the BDSC were encompassed in the Host-Microbial Analytic and Repository Core (H-
MARC). When these services were initially conceived of as part of the H-MARC, the focus was principally on
analysis of microbiome data. However, the scope of research among CMSDLD members has evolved
dramatically in the last 5-10 years, now including multiple omics domains. These different types of high-
dimensional data require unique analytic approaches. The BDSC has expertise in analyzing each of these data
types, thereby bringing an efficient solution to the diverse needs of the CMSDLD investigators. Additionally, while
the CMSDLD was founded to focus on molecular aspects of digestive and liver diseases as studied
predominantly in small animal models, there has been increased focus on human subject research. The BDSC
provides consultation and research support services for investigators wishing to pursue human subject and
translational research. The evolution from animal models to human subject research is consistent with the overall
goals of the CMSDLD to conduct research with the potential to impact human health along the theme of host-
environmental interactions in digestive and liver disease research from bench to bedside.
The BDSC is directed by Hongzhe Li, PhD, Professor of Biostatistics and co-directed by James D. Lewis, MD,
MSCE, Professor of Medicine and Epidemiology. Together, they bring decades of experience in research related
to gastrointestinal and liver disease, with specific expertise in applied and theoretical biostatistics, and human
subject research design, implementation and education. Moreover, although this is a newly created core within
the CMSDLD, Drs. Li and Lewis have a long track record of collaborating together and with other members of
the CMSDLD.
The core services to be provided by the BDSC include: (i) providing consultative services to support the design
and analysis of clinical and translational research, (ii) supporting the use of clinical and translational research
databases and (iii) providing biostatistics and bioinformatics support including standard and customized
analytics. Together, these services are designed to increase the quality and efficiency of CMSDLD investigators’
research and facilitate the continued evolution of CMSDLD’s focus on translational research.

## Key facts

- **NIH application ID:** 10889065
- **Project number:** 5P30DK050306-28
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Hongzhe Lee
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $146,250
- **Award type:** 5
- **Project period:** 1997-07-01 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10889065

## Citation

> US National Institutes of Health, RePORTER application 10889065, Biomedical Data Science Core (BDSC) (5P30DK050306-28). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10889065. Licensed CC0.

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