# Optoeletronic Micro-Gadget (OMG): a Photoelectrochemistry-Enabled Multi-Utility Lab-on-a-Chip System for Precise and Localized Sensing and Actuation

> **NIH NIH R21** · OHIO STATE UNIVERSITY · 2024 · $186,938

## Abstract

PROJECT SUMMARY/ABSTRACT
Problem statement: The investigation and manipulation of complex biological systems require lab-on-a-chip
(LOC) systems that can perform spatially resolved, localized sensing (e.g., detection of biomarkers) and
actuation (e.g., micropatterning, and electrical stimulation) on a single entity (e.g., within the surface of a soft
tissue). Faradaic electrochemistry involving reduction/oxidation (redox) reactions is commonly used as the
driving force for these operation modalities and processes. However, array-type electrodes prepared by
conventional lithography-based technologies have limitations in their flexibility as the dimensions, designs, and
locations are tailored to specific tasks, making it difficult to adjust the regions of measurement/manipulation of
dynamic cellular processes as required. Additionally, redesigning these electrodes requires time-consuming,
expensive, and highly sophisticated fabrication and read-out procedures. Furthermore, the predetermined
geometry may limit the achievable density of effective working sites due to the use of conductive
pads/interconnects within the electrode arrays. As a result, there is a need to explore novel LOC systems with
improved resolution, flexibility, and adaptability to shift the paradigm of spatially resolved biosensing and
actuation applications.
Hypothesis: This project aims to develop a photoelectrochemistry-enabled multi-utility lab-on-a-chip (LOC)
system, known as the "optoelectronic micro-gadget" (OMG), for sensing and actuation by utilizing cross-
disciplinary expertise in electrical engineering, optoelectronics, and analytical chemistry. The OMG system will
be based on a monolithic, flexible silicon thin film (thickness < 10 μm) and a reconfigurable focused laser beam
for spatially resolved photoexcitation. The working principle is that, when the semiconductor thin-film contacts a
redox solution, a space-charge region develops at the interface due to the Fermi energy level mismatch. A
photoexcitation will result in the generation of electron-hole pairs that are delivered to the semiconductor-
electrolyte interface, causing charge transfer and triggering redox reactions that can be used for amperometric
sensing and actuation in the localized spot. The hypothesis is that the flexible OMG system can achieve accurate
light-induced sensing and actuation within a single entity of curvilinear surfaces at a cellular or sub-cellular
dimension scale, and thus can serve as a powerful tool for biomedical investigation supporting multiple operation
modalities such as biosensing, micropatterning, pH regulation and electrical stimulation. The study will include
the following aims:
Aim 1: Develop flexible photoelectrodes supporting light-induced redox reactions.
Aim 2: Integrate the photoelectrodes with an optical system and test the feasibility of conducting spatially
resolved, localized photoelectrochemistry.
Aim 3: Evaluate performance/multifunctionality of “OMG” for applic...

## Key facts

- **NIH application ID:** 10889345
- **Project number:** 1R21EB035153-01A1
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Jinghua Li
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $186,938
- **Award type:** 1
- **Project period:** 2024-08-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10889345

## Citation

> US National Institutes of Health, RePORTER application 10889345, Optoeletronic Micro-Gadget (OMG): a Photoelectrochemistry-Enabled Multi-Utility Lab-on-a-Chip System for Precise and Localized Sensing and Actuation (1R21EB035153-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10889345. Licensed CC0.

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