PROJECT SUMMARY/ABSTARCT Disorders of gut-brain interaction (DGBI; formerly known as functional abdominal pain disorders) like irritable bowel syndrome are highly prevalent worldwide in children and adults. They are associated with significant morbidity and incur substantial healthcare costs. The etiology of DGBI is multifactorial as described by the biopsychosocial model. Psychological distress, including anxiety and depression, is highly associated with DGBI, and cognitive behavioral therapy and its variant guided imagery therapy (GIT) are efficacious first-line treatments per experts and clinical guidelines. Unfortunately, individual and systemic barriers often impede regular in-person therapy visits. Alternatively, researchers have demonstrated that remotely delivered CBT and GIT via compact discs and websites are efficacious, which led to the development of a K23-supported, patient-centered guided imagery therapy mobile application (GIT App). However, our current K23 research nor the medical literature inform best practices for implementing such a therapeutic App in pediatric clinics. Further, our preliminary data shows that our clinicians infrequently refer children with DGBI to any psychological therapy. This proposal aims to identify our clinic personnel’s perceived implementation determinants (i.e., barriers and facilitators) for rolling out the GIT App within our pediatric clinics. To address this known barrier and discover unforeseen barriers and inherent facilitators possibly affecting the implementation process, this proposal will solicit our clinic personnel’s perspectives of these factors to inform a future GIT App implementation strategy that can guide clinic personnel activities necessary to promote the implementation of the GIT App in this setting. Guided by the theory of Organizational Readiness for Change and the Consolidated Framework for Implementation Research, we will use qualitative and quantitative research methods to (1) assess our clinicians' perspectives about the infrequent referral of patients with DGBI to psychological therapy and (2) identify perceived barriers and facilitators to the implementation of the GIT App intervention in our pediatric clinics. Aim 1 will involve qualitative interviews with clinicians to better understand their views on barriers to referral. For Aim 2, we will use mixed-methods research by first quantitatively assessing clinic personnel’s organizational readiness for implementing the GIT App intervention within our pediatrics clinics by using the validated Organizational Readiness to Change Assessment (ORCA) instrument. Then we will conduct qualitative interviews with the same clinic personnel who have highest and lowest ORCA readiness scores and capture their respective perspectives about perceived barriers and facilitators affecting GIT App intervention implementation. The combined results of Aims 1 and 2 will inform a GIT App implementation strategy for our pediatric clinics that can be...