The Biostatistics and Database Core E is an integral part of this program project grant (PPG) “From cells to complex syndromes: Using networks to understand heterogeneity in TDP-related frontotemporal degeneration and aging” at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM). The goal of Core E is to support the data management, database, statistics, bioinformatics, and related computational needs of the PPG investigators. The services provided by Core E include: (a) support for data form/questionnaire design and development, database development and management, data entry, database audit trail, database security, database backup, and stringent data quality control procedures, (b) computing and programming support for all PPG activities, including implementation and integration of hardware and software upgrades necessary for data management and research, routine and archival off-site backup of computing systems central to the PPG, (c) biostatistical support for all study aspects of Projects and Cores from inception to publication, including development of study design, performing sample size and power calculations, and performing analyses of the PPG data, (d) support graph theoretic analysis in collaboration with the Neuroimaging Core C, (e) development of new statistical methodologies and extension of existing methodologies where needed for analyses of the PPG data, Thus, Core E plays an important and significant role that is critical to the progress of research and the conduct of studies in the PPG.