# Clinical

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2024 · $931,558

## Abstract

PROJECT SUMMARY—Clinical Core (Core B)
The overarching goal of this Program Project Grant (PPG) has been to advance knowledge of the neurological,
cognitive, behavioral, imaging, plasma biomarker, genetic, and neuropathological features of frontotemporal
dementia (FTD). In this renewal, the Administration and Clinical Cores are separated to meet the new scientific,
technological, and leadership demands of this PPG. With renewal, the Clinical Core will oversee the recruitment,
evaluation, and maintenance of cohorts that serve all the PPG cores and projects. New tools and approaches
will be used to translate FG years of discovery into innovative approaches for FTD clinical trials. We will refine
language and emotion symptoms and track their progression with traditional and automated techniques, obtain
accurate antemortem molecular prediction, gain a better understanding of caregiver vulnerability and its influence
on patient outcomes, and understand heterogeneity in FTD progression. The Clinical Core has added faculty
and research staff to focus on inclusion of a more diverse patient population and will add longitudinal
assessments designed to provide effective and scalable biomarkers needed for early diagnosis and monitoring
of treatment strategies. We will leverage tools and procedures developed as a response to the COVID-MN
pandemic to implement a hybrid model of in-person and remote, web-based assessment that will increase
recruitment, favor retention, and minimize patient and caregiver burden. The specific aims of the Clinical Core
are: Aim M. Recruit and longitudinally evaluate RFS new patients with FTD-spectrum disorders and their family
caregivers, patients with language and non-language variants of Alzheimer’s disease, and functionally intact
healthy controls, with renewed effort to include individuals from underrepresented groups. Aim F. Ensure a
comprehensive, standardized, quantifiable, and innovative clinical evaluation of each subject that includes
remote and in-person measurements. Aim V. Obtain three annual hybrid in-person and remote assessments.
The Clinical Core will continue to influence the landscape of FTD research and clinical care by providing the
best-characterized and largest single-site cohort of patients in the world.

## Key facts

- **NIH application ID:** 10890577
- **Project number:** 5P01AG019724-22
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** BRUCE L MILLER
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $931,558
- **Award type:** 5
- **Project period:** 2002-09-01 → 2028-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10890577

## Citation

> US National Institutes of Health, RePORTER application 10890577, Clinical (5P01AG019724-22). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10890577. Licensed CC0.

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