# Neuroimaging Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2024 · $571,334

## Abstract

PROJECT SUMMARY: Neuroimaging Core
The Neuroimaging Core (NC) plays an integral role in the UC Davis (UCD) ADRC scientific mission by
providing imaging-based structural and functional markers of aging and disease processes. These imaging
biomarkers support the primary aim of the UCD ADRC to understand factors that influence cognitive
trajectories from normal aging to dementia. Building on nearly 15 years of success, the NC will continue to
provide services related to acquisition, storage, post-processing and dissemination of imaging data. In addition,
the NC will collaborate with other departments at UC Davis as well as other institutions to develop novel state-
of-the-art methods for measuring the lifespan course of brain injury leading to dementia.
The Aims of the NC reflect the steady progression of its capabilities. The NC is now a mature component of the
ADRC that enriches the other Cores and the AD research community. It currently provides raw images to the
Clinical and Neuropathology Cores to support diagnostic activities. The NC also provides validated state-of-
the-art measurements of brain structure and function to the Data Management and Statistics Core and other
collaborating centers to support research projects. Finally, the NC works with the Research Education
Component and the Outreach Recruitment and Education Core to train investigators in neuroimaging methods
and disseminate information regarding imaging related research.
The addition of Dr. Audrey Fan to the NC brings a new dimension of expertise in the use of MRI and PET
imaging for new biomarkers of vascular disease, aging and cognitive change. In addition to imaging acquisition
expertise, she provides a strong link to the Biomedical Engineering Department at UC Davis and to new
facilities such as the total-body EXPLORER PET scanner. The novel imaging strategies and kinetic modeling
approaches from Dr. Fan’s lab complement existing NC research capabilities.
With over 20 grants, including SCAN, currently supporting image acquisitions and processing by the NC, we
provide benefits national and international collaborations that are far beyond the level of Core funding. The
overall goals of the NC to image brain injury leading to dementia aligns with the National Alzheimer’s Project
Act (NAPA) mission to identify pre-symptomatic AD, establishing early imaging biomarkers through large
public-private studies such as ADNI. The goals of NC are to continue to provide essential resources to the
UCD ADRC and build new capabilities at the forefront of neuroimaging.

## Key facts

- **NIH application ID:** 10890774
- **Project number:** 5P30AG072972-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Audrey Peiwen Fan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $571,334
- **Award type:** 5
- **Project period:** 2021-08-15 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10890774

## Citation

> US National Institutes of Health, RePORTER application 10890774, Neuroimaging Core (5P30AG072972-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10890774. Licensed CC0.

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