SUMMARY FOR CORE B The Imaging Core will provide comprehensive support for the in vivo imaging studies within the PPG projects. The core will be operated at the BioMedical Engineering and Imaging Institute (BMEII) at Mount Sinai under the direction of Core Director Dr. Philip Robson (Mount Sinai). Other members of this core will include dedicated image analysts, data managers, and other coordinating support staff at Mount Sinai. The Imaging Core will consist of an expert panel to incorporate expertise across all program project areas. The panel will review imaging and data analysis protocols at inception and periodically during the projects to optimize and update protocols employed in the program. Leveraging the existing experience, expertise, and infrastructures of the current ongoing Program Project and Clinical Trials Unit (CTU) at BMEII, a group dedicated to operating imaging-based clinical-trial-like research studies for intra-mural, extra-mural, and industrial collaborators, the core members will assist with the technical imaging protocol development and implementation as well as supervise image analysis for all Projects. In addition, the core will also serve as the image and data repository for imaging data obtained from this Program Project Grant (PPG). The Imaging Core will also fulfill the role of an “academic research organization” (an activity we have a substantial amount of experience in) for the two- center human clinical trial proposed in Project 4 and be responsible for the validation of all systems used for imaging and analysis, tracking data flow including maintaining an audit trail, operational management of the trial and ensuring compliance with all federal and regulatory guidelines. Finally, the Imaging Core will be responsible for centralized management of all the imaging data acquired as part of this PPG.