SUMMARY FOR CORE C The Biomedical Engineering Core C will support this program project's nanotherapeutic studies. The Core will operate from Mount Sinai under the direction of Dr. Abraham Teunissen, an expert in nanotechnology and organic chemistry. Dr. Teunissen also has extensive expertise in leading teams of scientists through his roles as Director of Mount Sinai’s Radiochemistry Facility and co-Director of our Nanomedicine lab. The Core will provide trained immunity-inhibiting nanobiologics for modulating stress-induced immune reprogramming in Projects 2 and 3. The Core will provide these nanotherapeutics on demand and arrange their transport to all collaborators. Moreover, Dr. Teunissen’s expertise enables this Core to efficiently respond to newly discovered therapeutic targets by developing novel nanoformulations.