Contact PD/PI: IMPERATO-MCGINLEY, JULIANNE L OVERALL PROJECT SUMMARY/SUMMARY The Weill Cornell Medicine Clinical and Translational Science Center’s (CTSC) future strategies are built on the considerable accomplishments achieved over the last 14 years, providing the translation of research and the generation of research ideas that pave the way for future innovations despite the effect of the pandemic on the medical school, with the city in lockdown for over 14 months. The plans for the next five years are devised to continue to develop the existing infrastructure and its initiatives, to add new ones, to enhance networking, and to improve diversity, equity, and inclusion. In so doing, we will continue to advance translational science to improve community health. With our multi-institutional hub of distinguished partners firmly in place, the strategic plans for the CTSC are geared to rapidly advance translational science discovery by: 1) Enhancing informatics to increase resource adoption, reduce roadblocks and streamline workflow through training, novel software, and new collaborations; 2) Improving health inequities, developing strong translational research engagement with communites, and preparing for health crises, like the COVID-19 pandemic, where the CTSC organized a vaccination hesitancy program and set up vaccination sites in underserved communities; 3) Continuing to develop our highly successful clinical and translational education programs through innovative and entrepreneurial multifaceted initiatives including training in health disparities and a new cross-hub KL2/TL1 collaboration with the Georgetown/Howard CTSA; and 4) Creating Team Science initiatives that promote inclusion across the CTSC. Innovative didactic opportunities will continue to be offered and expanded, such as seminars on innovation and entrepreneurship, the newest of which will be a collaborate with eLab on “Unmet Needs for Stimulating Device Development,” a five-part series which is designed to stimulate device development. The Pilot Translational and Clinical Studies program will be enhanced to target projects in device and therapeutics development, precision medicine and research in special populations while promoting collaborations between the community, community organizations and CTSC Investigators. The CTSC also offers educative opportunities that reach the broader community such as our Teaching Ethics Through Art program, while the Special Population Network (SPN) will expand to include community outreach studies and continue clinical research studies with a focus on the following populations: children, the elderly, ethnic and racial minorities and those with disabilities. Additionally, the Network Capacity Component will do more outreach to encourage local investigators to initiate multi-center clinical trials. The CTSC has also been extremely successful ensuring the availability of biostatisticians from all partners with expertise in diverse disease systems and...