PROJECT SUMMARY This proposal describes our research training program in the Division of Pulmonary and Critical Care Medicine (PCCM) at OHSU. In this program, we offer a multidisciplinary approach to pulmonary research and medicine that integrates state-of-the-art basic science, clinical trials, and patient outcomes research. Three postdoctoral fellows (MD or PhD) and three graduate students will be offered one and possibly two years of research funding. Research will be supplemented by trainee participation in program-wide research seminars, journal clubs, and didactic coursework. It is our belief that such program-wide meetings and interactions are vital to providing young scientists with a broad perspective on research outside their own projects, avoiding early overspecialization and an inappropriately narrow research focus. Coursework includes a program-specific course on pulmonary disease and research, Perspectives in Pulmonary Medicine. We will also offer a wide range of courses appropriate to trainees embarking on a research career. These include experimental design, grant writing, manuscript writing, human investigations, epidemiological methods, and career development. These are offered in our graduate programs, our OCTRI Human Investigations Program, and other University departments. Research mentorship is provided by a faculty of seasoned scientists with extensive experience in training young scientists. About half the faculty conducts research primarily involving the lung. The remainder have specific areas of expertise in cell and molecular biology that are frequently applied to the study of lung diseases. Interactions and synergy among the laboratories in this program add to the rich and broad training environment. Our trainees have been very successful given the relative youth of our training program, including achieving independent research funding, faculty or industry positions in biomedical research, and postdoctoral positions at other prestigious institutions.