Abstract Although much progress has been made with the Human Papilloma Virus (HPV) vaccine, still some communities lag in HPV vaccination rates. Reasons for this vary. HPV vaccination is lowest among Hispanic/Latinos/Latinas(H/L), Asian adolescent boys and H/L adolescent girls of non-US-born parents and for adolescents of African immigrant parents living in the U.S. These include indigenous groups from Latin America (Amerindians) and Africa (Ethiopians, Nigerians, Senegalese) In Los Angeles. LA data show one-fifth of parents from H/L, African ancestry, and Chinese American families (n = 357) high HPV vaccine resistance and over 50% worried about safety or side effects. Research shows low health literacy on HPV related factors, vaccine misconceptions are important factors contributing to low vaccine uptake in these groups. Further, though HPV is not gender-specific, the feminization of HPV with a focus on cervical cancer has been impacted by its sexual transmissibility; and this in turn has influenced the acceptance of HPV related information and its application among boys and men, especially lacking has been information on other HPV related cancers and culturally tailored, age appropriate and in language materials for immigrant origin groups. The USC Norris Comprehensive Cancer Center (USC NCCC) proposes to work on Track 1 (youth and adolescents) to develop and test a communication campaign with culturally and age-tailored educational materials on HPV related cancers and promote initiation of the HPV Vaccine among both male and female adolescent/young adults (10-30ys) in the HL, Chinese and African American/African-origin immigrant communities. We will collaborate with community partners Barrio Action Youth Center, Celebrate Life Black Churches Ministry, Vision y Compromiso, and 7 local FQHC clinics part of Clinicas Monsenor Oscar Romero, and the Chinatown Service Center (CSC), and Vision y Compromiso (promotores de salud). Leveraging USC NCCC Cancer Center COE resources and informed by findings from our previous administrative supplement (Tsui/Baezconde-Garbanati) we will extend our reach to both male and female vulnerable adolescents/young adults (AYA) in diverse audiences. Both quantitative (pre and post campaign) and qualitative data from listening sessions and focus groups will support development of campaign elements and its evaluation. Cultural experts and age-appropriate experts (including adolescents), our Community Advisory Committee and partners will support campaign development. We will use Artificial Intelligence (AI) technology/platforms to produce age and culturally appropriate educational materials in language. Proof of vaccinations will be via medical records review and reports by our FQHC clinics regarding consented participants. Community partners will help identify, train, and establish a community workforce composed of community health educators and promotores de salud for dissemination.