# Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification

> **NIH NIH R01** · CITY COLLEGE OF NEW YORK · 2024 · $326,560

## Abstract

PROJECT SUMMARY/ABSTRACT
Using enantioenriched organometallic nucleophiles in transition metal-catalyzed carbon-carbon
bond-forming reactions, we aim to develop general tools for the rational manipulation of three-
dimensional molecular structure. By introducing absolute stereochemistry prior to the formation
of a final stereogenic center, and reliably transferring this stereochemistry via stereoretentive or
stereoinvertive cross-coupling processes, the rapid preparation of diverse libraries of single-
enantiomer drug candidates for use in biological assays will be achievable. The use of
enantioenriched secondary alkylboron and alkylstannane nucleophiles will be explored in Pd-
and Cu-catalyzed alkyl-aryl and alkyl-alkyl cross-coupling reactions, with particular focus on the
derivatization of medicinally relevant organic frameworks and chiral structural motifs that are
currently inaccessible but are of biological or pharmaceutical interest.

## Key facts

- **NIH application ID:** 10892782
- **Project number:** 5R01GM131079-06
- **Recipient organization:** CITY COLLEGE OF NEW YORK
- **Principal Investigator:** Mark Roger Biscoe
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $326,560
- **Award type:** 5
- **Project period:** 2018-09-15 → 2027-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10892782

## Citation

> US National Institutes of Health, RePORTER application 10892782, Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular Diversification (5R01GM131079-06). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10892782. Licensed CC0.

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