# Reassortment of Bunyavirus in ticks and animal models

> **NIH NIH R01** · CLEVELAND CLINIC LERNER COM-CWRU · 2024 · $577,846

## Abstract

Project Summary/Abstract
Listed in the WHO top nine most dangerous pathogens, SFTSV has 12-30% fatality rates, rapidly
spreads through tick-to-animal/human, human-to-human and animal-to-human and induces
immunopathogenic disease with a characteristic thrombocytopenia. Virus reassortment is a process
of genetic recombination that is exclusive to segmented RNA viruses in which co-infection of a cell
of natural host and vector with multiple viruses may result in the shuffling of gene segments to
generate progeny viruses with novel genome combinations. Reassortment greatly affects virus
fitness and directly influences antigenic variation, confounding available methods of virus control. In
this application, we will test the hypothesis that tick-mediated natural course of SFTSV infection and
reassortment introduces phenotypic changes of fitness, transmissibility, antigenicity, or pathogenicity
into progeny reassortants. The goal of this study is to demonstrate the natural course of SFTSV
infection and reassortment for fitness, immunogenicity, transmissibility, and pathogenesis in in vitro
and in vivo animal models and H. longicornis ticks, ultimately bridging basic research to clinical
application.

## Key facts

- **NIH application ID:** 10892804
- **Project number:** 5R01AI171201-03
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Jae U Jung
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $577,846
- **Award type:** 5
- **Project period:** 2022-08-19 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10892804

## Citation

> US National Institutes of Health, RePORTER application 10892804, Reassortment of Bunyavirus in ticks and animal models (5R01AI171201-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10892804. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*