# Project 1: Genetic Discovery Within Diverse Ancestry Cohorts

> **NIH NIH U19** · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · 2024 · $855,242

## Abstract

PROJECT SUMMARY
The genomics of Alzheimer Disease is complex and evidence to date suggests that different ancestry groups
have distinct genetic factors that influence risk. In this project, we will perform multiple statistical analyses of
generated genetic data in African American, African, and Hispanic/Latinx populations to identify genetic factors
that are distinct within those groups. We will develop and apply new methods for identifying regulatory elements
and leveraging admixed chromosomes that are features of these populations. Finally, we will summarize results
through polygenic and pathway analyses to identify specific molecular mechanisms that harbor genetic variants
influence Alzheimer risk in each of these populations.

## Key facts

- **NIH application ID:** 10892913
- **Project number:** 5U19AG074865-03
- **Recipient organization:** UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- **Principal Investigator:** William S Bush
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $855,242
- **Award type:** 5
- **Project period:** 2022-07-01 → 2027-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10892913

## Citation

> US National Institutes of Health, RePORTER application 10892913, Project 1: Genetic Discovery Within Diverse Ancestry Cohorts (5U19AG074865-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10892913. Licensed CC0.

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