PROJECT SUMMARY/ABSTRACT ADMINISTRATIVE CORE The objective of the Administrative Core is to provide scientific leadership and operational management of The Jackson Laboratory (JAX) Cellular Senescence Collaborative (JAX-Sen) Tissue Mapping Center (TMC) in support of SenNet goals to map cellular senescence and its associated secretory phenotype in healthy mouse tissues. The Administrative (Admin) Core will provide the infrastructure to support all communication, coordination, oversight and management functions of the proposed center through a Governing Committee (GC) comprised of all PIs and Core Leads, an experienced Program Manager, and outside guidance from NIH program officials as necessary. Through a thoughtful Leadership Plan, the Admin Core will provide the overall governance of JAX-Sen that ensures robust communication within JAX-Sen and with other SenNet TMCs (Aim 1). The Admin Core will organize and oversee regular scientific meetings to foster communication and synergy within and across JAX-Sen, and to nurture a strong, collaborative environment across JAX-Sen’s two project sites (The Jackson Laboratory and UConn Health), across JAX-Sen and KAPP-Sen, a SenNet-funded human Tissue Mapping Center also based at JAX and UConn Health, and across SenNet consortium stakeholders, namely the Technology Development Centers, other TMCs, the CODCC, the SenNet Steering Committee, and NIH program officials. Through a Tissue Mapping Center Coordination Plan, the Admin Core will also coordinate the development of animal cohorts, collection of mouse tissue samples, data generation, data analysis and resource and data sharing within JAX-Sen (Aim 2). The Admin Core will provide scientific and administrative oversight of the Biological Analysis and Data Analysis Cores. This oversight, administered by the Program Manager, will include risk assessment and decision-making, project management, timely preparation of reports, and data quality reviews at regularly scheduled meetings with Core Leads. Through a Network Coordination Plan, The Admin Core will also coordinate collaboration and communication with all members of SenNet to optimize resource sharing and contributions towards overarching programmatic goals (Aim 3). The Admin Core will collaborate with other SenNet sites and NIH program officials to design or improve Network operations and implement protocols. The Admin Core will work with the CODCC to optimize strategies for data collection and analysis, and to facilitate public access to SenNet data through the CODCC. The Admin Core will coordinate plans for collaborating with other murine and human TMCs on topics including but not limited to SOPs, assay protocols and data analysis, and pilot projects. The Admin Core will also oversee creative, synergy-generating collaborative activities that make use of JAX-Sen’s (and JAX’s) unique resources, expertise and infrastructure.