# NRSA Training Core

> **NIH NIH TL1** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2024 · $749,022

## Abstract

J. TL1 – TRAINING CORE: PROJECT SUMMARY/ABSTRACT 
The overarching goal of the Irving Institute’s NRSA Training Core is to bring together pre-doctoral and post-doctoral trainees from across the broad spectrum of medicine, the other health sciences, and the basic sciences 
at Columbia University (CU), and prepare them to be leaders of the next generation of clinical and translational 
investigators. The Training Core, designated as a TL1 by NCATS, is founded upon a typical NRSA T32 training 
program, but has unique and innovative features distinguishing it from other T32 programs including the 47 at 
CU. For example, the TL1 is deeply integrated into our overall Clinical and Translational Science Award (CTSA) 
Program hub training and education program, TRANSFORM (Training And Nurturing Scholars For Research 
that is Multidisciplinary), which enables trainees to participate in didactic and experiential programs, including 
programs focused on team-science, alongside scholars in the KL2 and Master’s Degree in Patient Oriented 
Research programs. The Irving Institute’s TL1 also differs from a typical T32 in its disease agnostic approach
to recruitment and enrollment of trainees, and the designed focus on Precision Medicine (PM). As such, the 
program is named TL1-PM. The focus on PM has been stimulated by the CU-wide initiative in PM. Based on 
experiences during the first funding cycle, as well as the evolution of PM programs at CU, the Specific Aims for 
the renewal are: Aim 1. To further develop and refine our innovative TL1-PM education and career development 
program, thereby empowering our scholars and trainees to use the principles of PM to engage in interdisciplinary 
team science across all translational domains, make new discoveries, and be equipped to implement those 
discoveries into clinical practice and patient benefit. This TL1 is innovative in its focus on PM, significant 
coursework and seminars, a structured career development curriculum, and requiring all trainees to take 
externships. In the next five years, new opportunities will be added, including some focused on team and 
implementation science. Less successful programs will be scaled back or ended. Aim 2. To demonstrate the 
effectiveness of existing and new programs through continuous monitoring and assessment for quality 
improvement, using NCATS Common Metrics as well as our local, customized metrics to evaluate the impact of 
our educational programs on research output and the career trajectories of our graduates. Aim 3. To accelerate 
dissemination of the results of novel educational delivery approaches, new methods for assessing trainee 
learning, and best practices for enhancing interdisciplinary team science skills, to our partners at CU, regional 
CTSA Hubs (TriCon), and CTSA Program network throughout the nation.

## Key facts

- **NIH application ID:** 10894261
- **Project number:** 5TL1TR001875-09
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Marisa N Spann
- **Activity code:** TL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $749,022
- **Award type:** 5
- **Project period:** 2016-07-01 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10894261

## Citation

> US National Institutes of Health, RePORTER application 10894261, NRSA Training Core (5TL1TR001875-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10894261. Licensed CC0.

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