# Core 3 - Epigenomics Core

> **NIH NIH P01** · DANA-FARBER CANCER INST · 2024 · $417,435

## Abstract

Project Summary – Core 3 – Epigenomics Core Broad Institute
The overall goal of the core is to study the key features of epigenetic features in myeloma and improve our
understanding of global gene regulation to deploy novel therapeutics that target key epigenomic factors. Cells
and cell states can be defined by their gene expression programs, and tumor cells commonly have deregulated
gene expression programs. This core will perform epigenomic analyses on clinical samples from Projects 1 as
well as preclinical samples in Project 2, 3 and 4 at bulk and single cell level. Specifically, samples will be obtained
from patients enrolled on the previous clinical trial (IFM/DFCI 2009) and the newer IFM-2020-02 trial (evaluating
an MRD-based therapeutic algorithms at time of diagnosis and at relapse) in Project 1. In each case, tumor cells
will be isolated in Core 2 using well established procedures. This core will perform analysis for epigenetic
regulatory factors. The core has capabilities to perform ATAC-seq, MINT ChIP-seq using low cell number (5000
cells; van Galen et al, Molecular Cell 2016 Jan;61(1):1-11), perform single-cell multi-omics (Ma et al, Cell, 2020,
183, 1103–1116.e20) as well as adopt innovative variations specifically needed to answer questions. The core
will help with analysis of the generated data and accurately chart maps of epigenetic modifications and related
chromatin structures in myeloma. It will work with Core 5 to help integrate these results with other genomic
correlates.

## Key facts

- **NIH application ID:** 10894605
- **Project number:** 5P01CA155258-12
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** Charles B Epstein
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $417,435
- **Award type:** 5
- **Project period:** 2011-12-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10894605

## Citation

> US National Institutes of Health, RePORTER application 10894605, Core 3 - Epigenomics Core (5P01CA155258-12). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10894605. Licensed CC0.

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