# Joint Biology Consortium Resource-based Center

> **NIH NIH P30** · BRIGHAM AND WOMEN'S HOSPITAL · 2024 · $893,027

## Abstract

PROJECT SUMMARY/ABSTRACT - Overall
Breaking down barriers to translational research is the key to finding new approaches to inflammatory arthritis
and related diseases in adults and children. Four years ago, with P30 support, we built the Joint Biology
Consortium (JBC), a shared infrastructure based at the Brigham and Women’s Hospital and Boston Children’s
Hospital, to accelerate the work of an arthritis-focused Research Community now spanning 18 research
centers across the United States and abroad. Based on the success of the JBC, we propose to continue and
expand the fundamental design of three Cores designed around the shared needs of JBC members to
enhance the efficiency of existing studies, facilitate innovation, and foster junior investigators.
1. The Administrative Core is the organizational heart of the JBC, coordinating operations and cultivating the
scientific potential of the JBC research network, coordinated through the JBC Web Portal. The JBC Synergy
Meeting and Visiting Professor program promote scientific interchange, the JBC Workforce Development
Group promotes a diverse and inclusive research pipeline, and the JBC Enrichment Program incorporates
innovations from award-winning mentors to support JBC Young Investigators via grant aims review, mentoring,
and 12 yearly JBC Microgrants of $5,000 to facilitate utilization of JBC services for pilot and feasibility studies.
2. The Human Biosamples Core provides “one-stop shopping” for adult and pediatric biospecimens essential to
research in arthritis and related diseases. The HBC leverages 19 distinct sources of samples. The new JBC
Recruitment Core provides targeted prospective recruitment from over 100,000 consented individuals based
on phenotype and, in many cases, genotype to build a unified pipeline for biospecimens across the lifespan.
3. The Cellular Systems Core provides resource- and expertise-intensive tools for arthritis research. Next-
generation sequencing tools include single-cell RNAseq, CITE-seq, ATAC-seq, T-scan, PhIP-seq, and spatial
transcriptomics, while protein-based services include CyTOF, tissue mass cytometry, and custom Luminex, all
analyzed with assistance and education from the new JBC Bioinformatics Core.
Spearheaded by committed investigators and mentors Director PI/PD Dr. Peter Nigrovic and Associate
Director and Co-PI Dr. Elizabeth Karlson, the JBC spurs innovation within a deliberately inclusive and highly
collaborative network of senior and junior investigators, enabling the Joint Biology Consortium to continue to
grow as an engine of translational research in adult and pediatric arthritis and related disease.

## Key facts

- **NIH application ID:** 10894658
- **Project number:** 5P30AR070253-09
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Peter A Nigrovic
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $893,027
- **Award type:** 5
- **Project period:** 2016-08-11 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10894658

## Citation

> US National Institutes of Health, RePORTER application 10894658, Joint Biology Consortium Resource-based Center (5P30AR070253-09). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10894658. Licensed CC0.

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