# RFA-DP-23-002, Improving Health Outcomes for Patients with Inflammatory Bowel Disease through Evidence-based Awareness, Referral, and Education Programs

> **NIH ALLCDC U01** · CROHN'S AND COLITIS FDN OF AMERICA, INC. · 2024 · $737,676

## Abstract

Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease (IBD), are chronic
diseases with no cure. Although the United States (U.S.) is home to people of many different racial and ethnic
backgrounds, the incidence and prevalence of IBD within these racial and ethnic groups had not been well
described until the findings from the soon-to-be completed "Diversity within the Incidence, Prevalence,
Treatment and Outcomes of Patients with IBD (INPUT)" study funded by the CDC. Findings from the INPUT
study indicate that prevalence of physician diagnosed IBD is nearly 50% lower in non-White populations in the
U.S. This is particularly relevant for the 25% of IBD patients that are diagnosed with pediatric-onset IBD, in
which diagnostic delay is linked to an increased risk of complicated disease. Therefore, prompt diagnosis and
efficient treatment are of upmost importance in IBD populations to minimize permanent impairments.
Further, there is a growing awareness of the impact that social determinants of health (SDOH) have on health
disparities in IBD. SDOH are socially determined variables that impact health outcomes, and include racism,
discrimination, education, income, language and literacy skills, and nutrition access. In adult IBD populations,
racial, ethnic, and socioeconomic disparities are known to influence hospitalization, disease management, and
morbidity. Other psychosocial and demographic factors, including harmful ones, such as psychosocial stress
and trauma, food insecurity, barriers to care; and protective ones, such as adaptive coping, resilience, and
adequate health literacy, may also modify disease outcomes for pediatric and adult IBD patients.
African Americans often experience greater barriers to care, higher rates of psychosocial stress, and lower
levels of health literacy. This suggests that psychosocial factors and SDOH may put African American patients
at a much higher risk for poor outcomes. In this research, we will: 1) delineate the key psychosocial factors and
SDOH impacting timely diagnosis, health-related quality of life, and disease outcomes for IBD patients with a
focus on African American adolescents and adults; 2) utilize qualitative methods to identify the key barriers and
facilitators to health literacy-sensitive care, including timely diagnosis and effective management of IBD, for
IBD patients with a focus African American adolescents and adults; and 3) create awareness and educational
programs for physicians to be more likely to diagnose and effectively manage these patients, and for patients
and caregivers to increase their health confidence and be more engaged in their healthcare decision making,
while accommodating health literacy needs. The results of this work will provide a blueprint for addressing the
disparity in early and appropriately timed diagnosis and management of IBD in African Americans and
establish effective awareness and educational programs that can be implement...

## Key facts

- **NIH application ID:** 10895258
- **Project number:** 5U01DP006746-02
- **Recipient organization:** CROHN'S AND COLITIS FDN OF AMERICA, INC.
- **Principal Investigator:** Daniel I Chu
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** ALLCDC
- **Fiscal year:** 2024
- **Award amount:** $737,676
- **Award type:** 5
- **Project period:** 2023-09-30 → 2028-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10895258

## Citation

> US National Institutes of Health, RePORTER application 10895258, RFA-DP-23-002, Improving Health Outcomes for Patients with Inflammatory Bowel Disease through Evidence-based Awareness, Referral, and Education Programs (5U01DP006746-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10895258. Licensed CC0.

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