# Continuation of the University of Illinois Chicago CRIC Clinical Center

> **NIH NIH U01** · UNIVERSITY OF ILLINOIS AT CHICAGO · 2024 · $279,646

## Abstract

PROJECT SUMMARY
This application is submitted in response to RFA-DK-22-502, “Limited Competition: Continuation of the Chronic
Renal Insufficiency Cohort (CRIC) Study (U01)” on behalf of the University of Illinois Chicago (UIC) CRIC
Clinical Center. Since its inception in 2001, the CRIC Study has recruited and followed a racially and ethnically
diverse cohort of 5,625 participants with reduced kidney function from 13 recruitment sites at seven Clinical
Centers across the US. The original aim of CRIC was to establish a clinical research laboratory designed to (a)
identify novel predictors of CKD progression, and (b) characterize the manifestations of cardiovascular disease
and identify its risk factors among individuals with CKD. As the landmark prospective cohort study of CKD, the
CRIC Study has accomplished extensive biological, physiological, and social phenotyping, longitudinal follow-
up, and ascertainment of clinical and patient-centered outcomes across multiple domains. Findings from the
CRIC Study have defined trajectories of CKD progression, catalogued development and evolution of
comorbidities in CKD, and identified a diverse array of factors and pathways that explain the progression and
complications of CKD in adults. During the most recent funding cycle (Phase 4: 2018-2023), three innovative
sub-protocol studies were implemented to enrich CRIC data with highly granular home-based assessments of
kidney function and cardiovascular measures. During the fifth and final phase of the CRIC Study, the major
focus will be to (1) ascertain the clinical outcomes for all participants including those enrolled in the Phase 4
sub-protocols, (2) perform analyses linking the sub-protocol measurements to clinical outcomes, (3) integrate
data from multiple domains to identify sub-phenotypes underlying the heterogeneity in CKD progression
outcomes, (4) conduct final study visits for the full CRIC cohort eligible for Phase 5, (5) create mechanisms for
future data collection via linkages with external sources of health data, (6) generate tools and resources to
facilitate ongoing use of CRIC data and biospecimens by a broad group of investigators, and (7) support UIC
CRIC participant enrollment into the recently funded UIC Kidney Precision Medicine Project (KPMP) CKD
Recruitment Site. During the first four phases of the CRIC Study, the UIC research team enrolled nearly 1,200
participants and has been successful in retention, protocol implementation, data quality, and scientific
productivity. Additional noteworthy achievements include a strong focus on heath disparities in CKD, a
significant number of UIC investigator-led publications, leadership on funded ancillary studies, and the
promotion of new physician-scientists. Consequently, the UIC team is well positioned to make a substantive
contribution to the consortium by generating new scientific output and successfully transitioning the CRIC Study
from its active prospective cohort phase to a long-lasting res...

## Key facts

- **NIH application ID:** 10895441
- **Project number:** 5U01DK060980-24
- **Recipient organization:** UNIVERSITY OF ILLINOIS AT CHICAGO
- **Principal Investigator:** JAMES P. LASH
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $279,646
- **Award type:** 5
- **Project period:** 2001-09-28 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10895441

## Citation

> US National Institutes of Health, RePORTER application 10895441, Continuation of the University of Illinois Chicago CRIC Clinical Center (5U01DK060980-24). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10895441. Licensed CC0.

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