PROJECT ABSTRACT The Systems Marketing Analysis for Research Translation (SMART) Innovation Program brings a cutting- edge set of tools together to improve clinical and translational research effectiveness, efficiency, and equity and thereby enhance public health and health care delivery. The SMART Innovation Program supports CTSA Program Goals by (1) developing, demonstrating, and disseminating an operational innovation that improves the efficiency and effectiveness of clinical translational, (2) a structured, participatory method for promoting partnerships and collaborations to facilitate and accelerate translational research projects local, regionally, and nationally, and (3) creating and providing this with an explicit emphasis on addressing health disparities and deliver the benefits of translational science to all. More specifically, we build on our collective prior experience and collaboration combining community based-system dynamics as a participatory method for selection and tailoring of implementation strategies with a social marketing approach within a novel set-based concurrent engineering approach borrowed from manufacturing to accelerate translational research and health equity. Our primary hypothesis is that the integration of participatory system dynamics modeling with social marketing analysis improves clinical and translational research effectiveness, efficiency, and equity by reducing the complexity of translational research. The SMART Innovation program is designed to work with clinical researchers at any stage of the translational research continuum with an emphasis on the design of implementation strategies that maximize implementation outcomes of fidelity, reach, and sustainability of clinical interventions to promote health equity. More specifically, the SMART Innovation program begins with market analysis of the end user of the innovation (e.g., patient in the case of medication adherence, provider in the case of suicide screening and referral) to characterize the initial distribution of “demand” for the clinical innovation and its potential impact on reducing health inequities. This preliminary analysis provides the basis for a 2.5-day participatory group model building workshop with clinical researchers, implementation researchers, and end-users (or proxies, e.g., a patient navigator, advocate) to conceptualize the implementation context as a system, select and tailor implementation strategies, and refine an implementation. The program then supports the refinement of the analysis through a second phase of marketing analysis, leading to a more efficient translation of clinical and community innovations to improve health outcomes and health equity.