# Preventing Diabetes in Latino Families

> **NIH NIH R01** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2024 · $634,968

## Abstract

ABSTRACT:
Type 2 diabetes (T2D) disproportionately impacts Latino children, families and communities. T2D disparities
are the result of complex interactions that involve biological susceptibility and various interdependent social
determinants that represent the root causes of disease. The Diabetes Prevention Program (DPP) established that
T2D can be prevented in high-risk adults through intensive lifestyle intervention. Although the DPP has been
translated to a variety of adult populations and settings, engagement and effectiveness is diminished in minority
communities and there are no family-focused diabetes prevention trials for Latinos. For over a decade, our team
has collaborated to address the social and cultural determinants of diabetes among Latino youth, in the midst of
extant disparities in access to care, low health literacy, and certain cultural norms that may increase diabetes
risk. Our culturally-grounded approach is guided by an Ecodevelopmental model that considers community,
family, peer, and individual-level factors that influence health behaviors and health outcomes over time. Through
a series of increasingly rigorous studies we established that a lifestyle intervention can significantly reduce T2D
risk factors and increase Quality of Life (QoL) among Latino adolescents with obesity. We now propose to build
upon our extensive experience working with the local Latino community to rigorously test the efficacy of a
family-focused diabetes prevention intervention for reducing T2D risk and increasing QoL among high-risk
Latino families. We will use Integrative Mixed Methods to understand how family structures and processes
influence intervention outcomes. We will examine the sustainability of the intervention at 12-months and explore
mediators and moderators of long-term changes. Lastly, we acknowledge that the current translational gap
between scientific discovery and real-world impact must be closed so that evidence-based interventions are
expeditiously scaled to advance towards health equity for vulnerable and underserved populations. Therefore,
we will use the Exploration, Preparation, Implementation, Sustainment (EPIS) framework to guide areas for
adaptation and integration within key community-based organizations that may be well-positioned to adopt and
implement family-focused diabetes prevention programs. Our long-term goal is to build the evidence, network,
and capacity to scale multi-level, family-focused diabetes prevention programs across systems that serve
vulnerable and disadvantaged communities. As the next step towards this goal, we propose the following
Primary Aim: Test the efficacy of a 4-month, family-focused diabetes prevention intervention, compared to a
family control condition, for improving glucose tolerance and increasing QoL among high-risk Latino families.
Secondary Aim: Understand how family structure and family processes influence the reach, diffusion, and
impact of the intervention on the family system....

## Key facts

- **NIH application ID:** 10896148
- **Project number:** 5R01DK107579-09
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** Gabriel Quantum Shaibi
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $634,968
- **Award type:** 5
- **Project period:** 2015-12-23 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10896148

## Citation

> US National Institutes of Health, RePORTER application 10896148, Preventing Diabetes in Latino Families (5R01DK107579-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10896148. Licensed CC0.

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