# Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus

> **NIH NIH U01** · OHIO STATE UNIVERSITY · 2024 · $270,626

## Abstract

Project Summary/Abstract
Acute pancreatitis is a common inflammatory disorder with short- and long-term clinical
sequelae. The development of diabetes mellitus following an episode of acute pancreatitis
(termed AP-related DM) is now recognized in approximately 25% of patients; however, its
epidemiology and pathophysiology remain poorly characterized. These knowledge gaps limit
our ability to identify which patients are most likely to develop this metabolic complication and
design targeted prevention and treatment strategies. Therefore, we have developed a
prospective, longitudinal, observational cohort study in AP, along with a series of hypothesis-
driven investigations in AP-related DM. We propose The Ohio State University Clinical Center
(OSU-CC), an innovative, strategically aligned, multi-disciplinary team of nationally-recognized
experts to address knowledge gaps in AP-related DM and work collaboratively with other
selected Clinical Centers within the framework of the NIDDK to form the Type 1 Diabetes in
Acute Pancreatitis Consortium (T1DAPC).

## Key facts

- **NIH application ID:** 10896173
- **Project number:** 5U01DK127388-05
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** DARWIN LEWIS CONWELL
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $270,626
- **Award type:** 5
- **Project period:** 2020-09-17 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10896173

## Citation

> US National Institutes of Health, RePORTER application 10896173, Epidemiology and Pathophysiology of Acute Pancreatitis-related Diabetes Mellitus (5U01DK127388-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10896173. Licensed CC0.

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