The Administrative Core will coordinate efforts between the Projects and Large Animal and Microscopy Cores. Successful execution of the three projects that comprise this P01 are necessary to test the central hypothesis. Quantification of neocortical network structure (Project 2) and Cl-i and Cl-o (Project 3) must be measured as a function of time after brain injury and epileptogenesis (Project 1). These projects all utilize the same experimental cohort in order to reduce costs and animal usage. Thus close coordination among the projects is essential. Coordination of projects by the Administrative Core greatly facilitates simultaneous data collection and analysis on the same animals. Experiments and animal enrollment are staggered across the duration of the grant to minimize space requirements in the vivarium and operating room and maximize the efficient, continuous utilization of space and personnel. The Administrative Core will coordinate project meetings. Investigators currently meet monthly to review results of Phase I of this project (tool development). We plan to continue these monthly meetings to review progress, address problems, and coordinate research schedules. Coordination by the Administrative Core is described in this section of the proposal. The Administrative core will facilitate the interface of the P01 with external scientists and organizations. In addition to monthly meetings of projects and cores, the Administrative Core will also organize quarterly meetings with the investigators, consultants and the steering committee. At these meetings, the overall direction of the research will be reviewed, manuscripts will be discussed, and presentations at national and international meetings will be addressed. The administrative core will facilitate policy management and the execution of both internal and institutional policies relevant to the project. The administrative core will manage data transfer between projects, data archiving, and access to the data by external investigators. The Administrative Core will coordinate interactions with regulatory agencies, vendors, and professional organizations.