# A novel framework for nanomedicine development

> **NIH NIH R35** · UNIVERSITY OF OKLAHOMA · 2024 · $373,297

## Abstract

Project Summary
Nanomedicine is a research field centered around applying materials in the nanoscale size range (i.e.
nanoparticles) as therapeutics and diagnostics. However, a major challenge is the safe, efficient, and effective
delivery of nanoparticles to biological systems, such as cells, tissues, and organs. In this project, we will introduce
and explore a novel framework for nanomedicine development with the ultimate goal of efficiently delivering non-
viral nanoparticles to cells and tissues for safe and effective applications. Our proposed research program has
three main strands: (i) we will develop novel nanoparticles for the safe, efficient, and effective delivery of small
molecules and nucleic acid payloads to skeletal muscle cells; (ii) we will develop novel methods for super-
resolution bioimaging to study the mechanisms and kinetics of nanoparticle spatiotemporal transport in biological
systems; (iii) we will quantify safety, efficiency, and effectiveness of nanoparticle in vivo delivery. Using this novel
framework, our long-term scientific goal is to create a major breakthrough in nanomedicine by developing safer,
more efficient, and more effective nanoparticles for the non-viral delivery of small molecule-based drugs and
nucleic acid payloads to enable therapeutic applications in skeletal muscle disorders.

## Key facts

- **NIH application ID:** 10896232
- **Project number:** 5R35GM150758-02
- **Recipient organization:** UNIVERSITY OF OKLAHOMA
- **Principal Investigator:** Stefan Wilhelm
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $373,297
- **Award type:** 5
- **Project period:** 2023-09-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10896232

## Citation

> US National Institutes of Health, RePORTER application 10896232, A novel framework for nanomedicine development (5R35GM150758-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10896232. Licensed CC0.

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