PROJECT SUMMARY/ABSTRACT The overall goal of this application is to establish and characterize a large collection of minority patient-derived cancer xenografts (PDXs) from two cancer types (gastric and lung) and utilize these PDXs to guide cancer precision medicine decision making focusing on racial/ethnic minority populations. We established the University of California and UT Southwestern Diversity-PDX and Trial Development Center (UCaTS) that is built on an existing cancer health disparity research network, and includes six NCI-designated Comprehensive Cancer Centers: UC Davis, UC Irvine Health Chao Family Comprehensive Cancer Center (UC Irvine), UC Los Angeles Jonsson Comprehensive Cancer Center (UCLA), UC San Diego Moores Cancer Center, UC San Francisco Helen Diller Family Comprehensive Cancer Center (UCSF) and University of Texas Southwestern Harold C. Simmons Cancer Center (UTSW). The role of the Administrative Core is to coordinate the research effort among different campuses and to maximize the use of the funding and resources. The Administrative core members include UCaTS contact PI, who has conducted extensive research in PDXs and has national/international leadership expertise in cancer health disparities. The contact PI, Dr. Carvajal-Carmona, will be responsible for the overall program administration. Working closely with the contact PI, this Core will have support from a Biostatistician, five Site PIs, and a UCD CRC to help coordinate patient specimen collection, the two Research Project leads, and a grant administrator to operationalize UCaTS goals. The Administrative Core will maintain constant contact with the NCI staff, the PDXNet Data Commons and Coordinating Center (PDCCC), Patient- Derived Models Repository at Frederick National Laboratory for Cancer Research (PDMR-FNLCR), and other PDX Development and Trials Centers (PDTCs) to develop standard operating procedures (SOPs), coordinate research activities, cross-validate PDX research, and deposit PDX models into PDXNet. The Admin Core will be responsible for establishing and maintaining Center communication and fiscal management to ensure UCaTS will deliver its objectives in a timely manner.