# Molecular Mechanisms of Myosin-3

> **NIH NIH R01** · OHIO STATE UNIVERSITY · 2024 · $322,983

## Abstract

PROJECT SUMMARY/ABSTRACT
Our goal is to determine the molecular mechanisms of myosin-3 motors, unique kinase-myosin hybrids in the
myosin superfamily, that are involved in fundamental cellular processes including cargo transport and the
organization of the actin cytoskeleton in sensory cells. Despite their critical role in human biology, the molecular
mechanisms of myosin-3 motors are not well understood. We propose that different modes of regulation together
with different kinase substrates and binding partners determine the molecular mechanisms of myosin-3 motors.
An integrated and innovative biochemical, biophysical, cell biological and high-resolution structural approach will
be used to (i) determine the enzymatic profile and regulation, (ii) the unique structure (iii) and pathways that
control myosin-3 function and regulation in vitro and in cells. Collectively, these studies will reveal novel
mechanistic insights into the regulation of myosin-3 motors and have broad implications in the understanding of
how different myosins are tuned to organize actin networks in cells.

## Key facts

- **NIH application ID:** 10896342
- **Project number:** 5R01GM143414-04
- **Recipient organization:** OHIO STATE UNIVERSITY
- **Principal Investigator:** Sarah Heissler
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $322,983
- **Award type:** 5
- **Project period:** 2021-09-10 → 2026-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10896342

## Citation

> US National Institutes of Health, RePORTER application 10896342, Molecular Mechanisms of Myosin-3 (5R01GM143414-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10896342. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*