Core G: Biostatistics and Data Science Core ABSTRACT The Biostatistics and Data Science Core (Core G) is an essential component of Penn CFAR, maximizing statistical rigor and data quality in studies conducted by CFAR investigators and elevating junior researchers through mentoring and methodological guidance. Core G empowers CFAR investigators to engage in reproducible, high quality, impactful discovery. Core G provides (a) expertise in statistical design and analysis using classic and cutting-edge methodology; (b) database development and management; (c) leadership in advancing methodology for HIV-related research through evaluating, developing and disseminating innovative statistical approaches; (d) education, training, and mentorship in statistical methodology; (e) partnership with the Philadelphia Department of Public Health (PDPH) to enable high priority research relevant to implementers and people with HIV; and (f) a central nexus for engagement of the broad epidemiology, statistics and informatics faculty in high priority HIV/AIDS research. Core G is led by Drs. Alisa Stephens-Shields (Director) and Mary Putt (Co-Director), and Dr. Yun Li (Core Investigator) is Core G’s on-site representative at Children’s Hospital of Philadelphia (CHOP). Mr. Chris Helker oversees data management activities. Core G employs a statistical analyst based part-time at Philadelphia Department of Public Health (PDPH), creating an innovative research partnership by enabling direct access to restricted PDPH databases, and increasing analytic capacity at the PDPH Division of HIV Health (DHH). Core G provides statistical expertise to trainees working in the labs of CFAR investigators, provides study design, statistical analysis and data management guidance in developing new funding applications by CFAR investigators, and participates as project personnel when proposals are funded. Notably, Core G also provides crucial statistical collaboration to studies with limited resources for analysis, including Developmental Core and other studies that generate pilot data for subsequent extramural applications. The Core maintains the CFAR Clinical Core Adult/Adolescent Database of >3000 participants and the linked specimen repository, as well as multiple project-specific databases. Core G faculty are active mentors to CFAR trainees in basic and population science, including several mentees in Botswana through collaboration with the International Core. Looking ahead, Core G will provide leadership to clinical trials in HIV prevention, treatment and cure studies; continue to engage junior researchers and enhance their statistical knowledge through the newly implemented Help Desk tool and supporting Developmental awards; leverage our relationship with PDPH to advance Ending the HIV Epidemic (EHE) initiatives; expand involvement of biostatistics and informatics faculty in CFAR activities through connection of CFAR investigators to faculty with specialized expertise, in areas such a...