PROGRAM SUMMARY/ABSTRACT The CTSA Predoctoral T32 Program at The University of Texas Health Science Center at San Antonio is the companion institutional training grant for predoctoral graduate students. This Translational Science Training (TST) Program will provide predoctoral Trainees with innovative programing to help them develop those skills in team science, innovation, and scientific rigor necessary for a successful career in Translational Science (TS). Research training in TS and career development will develop a highly skilled workforce to efficiently advance patient-focused research from preclinical and clinical settings to clinical implementation and population health. Refined programmatic activities, including a required graduate-level TS Certificate, will ensure that Trainees recognize the relationship between applied TS and contemporary biomedical research. Monthly TST Program Meetings will reinforce TS concepts, community engagement, dissemination and implementation (D&I), diversity, equity, inclusion, and accessibility (DEIA), career development, mentoring, and wellness. Together with CTSA K12 Scholars, TST Trainees will participate in a new Clinical and Translational Science (CTS) Roundtable that integrates concepts in process innovation, systems thinking, and boundary crossing, along with team science and cultural diversity; K12 Scholars will serve as near-peer mentors for TST Trainees to further enhance interactions across the early career scientist workforce. Finally, community engagement, within the TS Practicum, will increase training opportunities that offer insight to better leverage the strengths of local populations, investigators, and resources. The TST Program Objectives are to: • Provide robust TS training for predoctoral Trainees, in the context of diverse science and cultures • Emphasize research with unique regional populations to address Hispanic and military/veteran health concerns • Enable didactic and experiential activities that contribute to team science knowledge and skills • Expand the workforce of well-prepared TS investigators • Evaluate programmatic components for continuous quality improvement