# The Adolescent Master Protocol (AMP) Up Series Project

> **NIH NIH P01** · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · 2024 · $249,444

## Abstract

PROJECT SUMMARY
The Centers for Disease Control and Prevention estimates that in 2016, there were 11,915 persons with
perinatally-acquired HIV (PHIV) in the U.S., including 10,101 adolescents and young adults. Globally, 1.7
million children under the age of 15 are living with HIV and with effective antiretroviral medications (ARVs) are
expected to survive into adolescence, young adulthood and beyond.
The Adolescent Master Protocol (AMP) was designed to evaluate long-term effects of HIV infection and
ARVs on multiple domains. AMP enrolled 451 children with PHIV between ages 7-16 years and 227 children
living with perinatal HIV exposure but uninfected (PHEU) from 2007-09. The AMP Up and AMP Up Lite
studies (AMP Up Series) were developed to allow for continued follow-up of young adults with PHIV
(YAPHIV) beyond 18 years of age, including AMP participants, to assess physical and mental health as they
transition to adulthood. These innovative studies share similar objectives and are designed to facilitate long-
term follow-up with annual online and medical chart abstracted data collection.
AMP has been highly productive with numerous influential publications. AMP Up has yielded important
information – including the role of social support and ability to self-manage health care on a successful
transition to adult clinical care, and the high risk of postpartum viremia and early HPV-associated cervical
lesions. Yet the long-term effects of HIV and ARV on health in young adulthood are still unfolding. The
comprehensive data collected since early childhood on a substantial subset of AMP Up participants previously
in AMP provides the invaluable opportunity to assess how early HIV and ARV, mental health, neurocognitive
function, and family dynamics impact adult outcomes. The specific aims of the AMP Up Series are to:
1. Define the impact of PHIV infection, ARVs, and individual, social and structural factors on: the transition to
adulthood and adult care; brain structure and neurological functioning; academic, vocational, emotional and
social functioning; mental health; medication and health care adherence; sexual behaviors; and substance use.
2. Identify infectious and non-infectious complications of HIV and their associations with ARVs and HIV.
3. Investigate genetic, epigenetic, virologic, inflammatory, and immunologic factors which impact the course of
HIV infection, its complications, the response to treatment, and potential for HIV remission/cure.

## Key facts

- **NIH application ID:** 10897167
- **Project number:** 5P01HD103133-05
- **Recipient organization:** HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH
- **Principal Investigator:** Katherine K. Tassiopoulos
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $249,444
- **Award type:** 5
- **Project period:** 2020-09-18 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10897167

## Citation

> US National Institutes of Health, RePORTER application 10897167, The Adolescent Master Protocol (AMP) Up Series Project (5P01HD103133-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10897167. Licensed CC0.

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