# IDD Models Core

> **NIH NIH P50** · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $196,311

## Abstract

The IDD Models Core is designed to foster development and analysis of human stem cell and
rodent models of IDD conditions. The core supports basic science studies of molecular pathways
and cellular interactions that are altered in genetic and epigenetic disorders affecting nervous
system function. In addition, the core enables drug and biomarker studies, as well as preclinical
studies that are aimed at developing novel translational approaches to IDD. A historic strength of
the IDD Models core is the use of human pluripotent stem cell (hPSC)-based models, which
include both patient-specific induced pluripotent stem cells (iPSCs) and their modification by
genome editing, to study diverse types of IDD conditions. The core has incorporated novel
approaches to meet the increased demands for rigor and reproducibility by meeting
international/peer institution standards in the creation and characterization of patient-specific
iPSCs and hESCs. The refined gene editing capabilities develop innovative cellular tools for
sophisticated analysis of altered nervous system development and function. These models also
provide the means to evaluate candidate therapeutics in disorder-relevant cells, as well as
develop novel screens to identify promising compounds in small- and large-scale library
screening. The core also empowers analysis of rodent models of IDD conditions, not only by
providing support for their creation, but also by providing a comprehensive and cutting edge
behavioral testing service. The service incorporates a battery of cognitive/nervous system
analyses under the supervision of a skilled core manager to ensure the rigor and reproducibility
of these IDD model studies. Our specific aims for the next project period are: (1) to create and
analyze human stem cell models of IDD; and (2) to create and analyze rodent models of IDD.
Recognizing that sophisticated analysis of these models is required to elucidate pathogenesis
and novel therapeutic approaches, the IDD Models Core uses extensive on-site research
resources and leverages an extended network of complementary research cores on the UW-
Madison campus to provide the infrastructure and skilled personnel that support integrated
analysis at molecular, genomic, epigenomic, cellular, electrophysiological, and behavioral levels.
Assembly of these diverse resources is designed to broaden the scope and depth of IDD model
studies and to facilitate progress of IDD research from basic science to translational studies.

## Key facts

- **NIH application ID:** 10897269
- **Project number:** 5P50HD105353-04
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** John P Svaren
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $196,311
- **Award type:** 5
- **Project period:** 2021-07-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10897269

## Citation

> US National Institutes of Health, RePORTER application 10897269, IDD Models Core (5P50HD105353-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10897269. Licensed CC0.

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