# Discovery and mechanisms of biosynthetic enzymes

> **NIH NIH R35** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $539,000

## Abstract

PROJECT SUMMARY
Biosynthetic pathways are rich in enzymatic transformations that produce structurally
diverse natural products, such as secondary metabolites, modified nucleic acids, and
modified peptides. Discovering and understanding the molecular basis for these
transformations underpins efforts towards development of deep insights into factors that
either belie many disease processes, or their use in development of therapeutic agents.
The focus of the proposed studies will be elucidating the mechanisms of enzymes that
employ radical transformations in effecting complex transformation in the biosynthesis of
ribosomally produced and posttranslationally modified peptides. This application will
make use of biochemical, structural, and spectroscopic techniques to probe the
mechanisms of these enzymes, establish structure-function relationships, and to discover
novel biosynthetic enzymes.

## Key facts

- **NIH application ID:** 10897699
- **Project number:** 5R35GM126956-07
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** VAHE BANDARIAN
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $539,000
- **Award type:** 5
- **Project period:** 2018-05-01 → 2028-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10897699

## Citation

> US National Institutes of Health, RePORTER application 10897699, Discovery and mechanisms of biosynthetic enzymes (5R35GM126956-07). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10897699. Licensed CC0.

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