This is a resubmission of the third competing continuation application of T32 HL082610, “Translational Research Training in Sleep and Circadian Science,” currently in Month 50 of our third 5-year grant period. The broad aim of this program is to train the next generation of clinical, basic, and population scientists in a translational approach to sleep and circadian science. This T32 is the nidus for sleep and circadian research training at the University of Pittsburgh (Pitt), attracting additional postdoctoral and graduate student trainees from other Pitt programs. Our T32 has enjoyed considerable success: 72% of 40 appointed and affiliated postdocs submitted F/K/CDA applications, 70% of these received awards, and 85% hold faculty or training positions. Our 29 medical students have submitted 17 abstracts and published 14 peer-reviewed papers. For the next 5-year period, we propose to deepen our focus on multidimensional sleep and circadian health (MSCH)— specifically, on its health consequences and mechanisms, and on interventions to improve MSCH. Our philosophy is that effective training in sleep and circadian science is multidisciplinary, translational, evidence- based, milestone driven, and socially conscious. Guided by this philosophy, our training program includes: A primary focus on mentored research with experienced, well-funded sleep medicine investigators; team mentoring, and careful evaluation of mentor and mentee progress; didactic work including core competencies in sleep and circadian research methods, critical appraisal of the literature, professional development, responsible conduct of research, and rigor and reproducibility; measurable outcomes, including trainee publications, presentations, and grant applications; individual and group instruction in the preparation of career development and other award applications; individually-prescribed formal coursework; and access to the rich training and research resources at Pitt, including the Clinical and Translational Science Institute (CTSI). The training program will include 3 components: 1) Continuing the 2-3 year postdoctoral training fellowship for nationally-recruited physician scientists and PhDs (4 trainees per year). 2) Continuing the short- term research program for medical students (4 trainees per year). 3) Adding a new 2-3 year training program for nationally-recruited predoctoral students in accredited Pitt graduate programs (e.g., psychology, neuroscience, epidemiology, health and physical activity) (4 students over 5 years). This new predoctoral program will formalize and provide a consistent support mechanism for the graduate student training we have already been conducting. We have systematically evaluated our program with our trainees, University Advisory Board, and External Advisory Board. Based on these evaluations, we propose to further strengthen the program with targeted recruitment efforts to increase the number of trainees from groups that are underrepresented ...