# Intercellular Communication in Retinal Development

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2024 · $39,342

## Abstract

Project summary/abstract
Using serial block-face scanning electron microscopy, we have produced the first adult mouse
retinal volume that spans the entire depth of the retina, from photoreceptors to the nerve fiber
layer at nanometer resolution to map mouse retinal cell types and their microcircuits. There are
currently no other mouse retinal volumes that encompass both the inner and outer retina.
Cellular ultrastructure and synaptic detail are excellent. Based on this volume, our goal is to
provide the community with the most complete first-draft connectome of the mouse retina
available anywhere within about a year. To achieve this, we propose to use Scalableminds
Voxelytics services to stitch together and register the images, then segment the entire volume
and detect ribbon and conventional synapses. These services will accelerate the availability of a
fully segmented volume of the mouse retina that will greatly benefit ongoing retinal circuitry
projects as well as facilitate new discoveries by the community.

## Key facts

- **NIH application ID:** 10898222
- **Project number:** 3R01EY010699-29S1
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Rachel O Wong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $39,342
- **Award type:** 3
- **Project period:** 1994-07-01 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10898222

## Citation

> US National Institutes of Health, RePORTER application 10898222, Intercellular Communication in Retinal Development (3R01EY010699-29S1). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10898222. Licensed CC0.

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