# Biostatistics and Bioinformatics Core

> **NIH NIH P50** · NORTHWESTERN UNIVERSITY · 2024 · $201,316

## Abstract

BIOSTATISTICS AND BIOINFORMATICS CORE: SUMMARY
The Biostatistics and Bioinformatics Core (B&B Core) is a central component of the Brain Tumor SPORE,
providing state-of-the-art integrated data science support to all Brain Tumor SPORE projects. Database
development and maintenance will provide a centralized resource for data tracking for preclinical studies,
ensuring efficient reporting and statistical analysis of all experiments. In addition, clinical databases will be
developed in conjunction with all project teams to complement existing clinical trial data registries at
Northwestern and ensure custom data capture in a highly secure environment. Bioinformatics activities of the
B&B Core are central to discovery and will help define new and significant research directions. The large
omics data sets that will be generated in the Brain Tumor SPORE Projects require specialized expertise for
preprocessing, analysis and interpretation of molecular and biological consequences of genetic manipulations
and treatments. Bioinformatics functionality provided by the B&B Core will provide this crucial assistance for
all proposed Brain Tumor SPORE Projects. Biostatistical activities of the B&B Core are central to the concerns
of rigor and reproducibility: by providing study design guidance, data management, statistical analysis and
consultation for interpretation of results the core will see that reported results have been rigorously controlled
and will be reproducible by others. All functions of the B&B Core will be conducted in association with the
following Specific Aims: AIM 1: Establish and maintain database functionality for all preclinical and clinical
data; AIM 2: Provide bioinformatics collaboration and support for pre-processing and analysis of high-
dimensional omics data, including array-based and sequencing data; AIM 3: Provide biostatistical collaboration
and support for design of preclinical studies and clinical trials, as well as statistical analyses of all accumulated
data. Through these activities the B&B Core will serve as a key contributor to all individual projects and will
ensure that project output is accurate, reliable, and of the highest quality.

## Key facts

- **NIH application ID:** 10898624
- **Project number:** 5P50CA221747-07
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Hui Zhang
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $201,316
- **Award type:** 5
- **Project period:** 2018-08-17 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10898624

## Citation

> US National Institutes of Health, RePORTER application 10898624, Biostatistics and Bioinformatics Core (5P50CA221747-07). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10898624. Licensed CC0.

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