Clinical/Translational (C/T) scientists who conceptualize health problems in new ways and utilize skills that both enhance interdisciplinary work in clinical and community settings and catalyze translational processes are vital to address the nation’s unmet health needs and achieve equity in health care. Building upon the successes of our existing C/T training programs for predoctoral students, post-doctorates, and junior faculty, and in collaboration with the Workforce Development and Community & Stakeholder Engagement Modules of our Clinical & Translational Science Collaborative, our Clinical and Translational Scientist Training Program for Post-doctorates (CTSTP-Post) will enable a diverse cadre of postdoctoral trainees to both ‘deepen’ their scientific domain expertise and develop the knowledge, perspective, and skills necessary to function efficiently and effectively as C/T scientists facing the opportunities and challenges of medicine and health in the 21st Century. We will also increase diversity in trainees and create a research environment welcoming to that diversity. Strategic partnership with Historically Black Colleges and Universities (HBCU) and other targeted institutions will increase the number of underrepresented minorities, persons with disabilities, and persons from disadvantaged backgrounds in our training program and, ultimately, into the C/T Science workforce. Through this program, twelve trainees will each complete a two-year appointment. Using a strategic combination of training activities – e.g., mentoring by a successful, experienced C/T scientist, coursework, observerships and other field experiences, workshops, symposiums, seminars/discussions – trainees will acquire deeper understanding of and sharpen their skills in translational processes, interdisciplinary research, team science, communication, systems science and complexity, community and stakeholder engagement, innovation, entrepreneurship and commercialization, dissemination and implementation science, information science and artificial intelligence, health disparities, professional and leadership development, responsible conduct of research, and methods for enhancing reproducibility. Our program will interact with the proposed CTSTP for Predoctoral Students and K12 Program for Junior Faculty, creating a rich culture of learning and exchange, where perspectives of different disciplines are represented and where trainees share ideas, challenge each other, and grow together. Although each program will be distinct and will have its own Internal Advisory (Steering) Committee and unique components, oversight of all three programs by a single Research Education Advisory Board, a shared mentor pool, strategically selected joint activities, and standardized evaluation approaches and tools will create synergies in training, leadership, and management across programs and assure attainment of program objectives.