PROJECT SUMMARY TRANSFORM SC – (Trials and ReseArch NetworkS FOR More) South Carolina is a statewide consortium of pediatric providers who collectively can reach virtually all children in the state of South Carolina. This consortium has all the critical elements for a center to be a successful collaborator in the IDeA States Clinical Trials Network (ISPCTN): adequate patient volume, creation and retention of an established clinical research infrastructure, a track record of outstanding subject enrollment, and a dedication to team- based science. These elements have allowed this South Carolina clinical site to be a highly successful and administratively active participant in the inaugural funding cycle of the ISPCTN. Furthermore, South Carolina investigators have participated in many leadership roles for the ISPCTN including Chair of the Publications and Presentations Committee (Atz), member of the ISPCTN Leadership Committee (Turley), and Chairs of ECHO clinical focus working groups (Atz- pre,peri, postnatal outcomes; Turley- positive health). South Carolina sites are represented in each and every one of the current and upcoming ISPCTN clinical trials. The combined resources of patient volume, research infrastructure and dedication have enabled TRANSFORM SC to be among the top subject enrollers in the ISPCTN.