Project Summary This Gordon Research Conference (GRC), “Endothelial Cell Phenotypes in Health and Disease”, and the accompanying Gordon Research Seminar (GRS) have the underlying hypothesis that an improved understanding of endothelial cell phenotypes provides basic knowledge crucial to promote vascular repair and enable tissue regeneration for the large collection of diseases with vascular dysfunction. The goals of this conference are to therefore to address existing knowledge and communication gaps by bringing together researchers at all levels who study endothelial cell biology and heterogeneity with those who study vascular disease, bioimaging, and tissue engineering and regenerative medicine. Each of these fields has recently developed novel paradigms, tools and models to bring forward this goal, and integration between the fields is predicted to move all of them forward towards the translation of basic discoveries into clinical benefit. The GRC Chair and Vice-Chair are leaders in the field and well-suited to organize the meeting. The Chairs will ensure that the meeting goals are accomplished by bringing together a selected group of 150 researchers to a small, semi-isolated site for a week, with a meeting structure designed to foster extensive discussion of largely unpublished data, and in a venue that promotes informal interactions and networking through shared meals and afternoon social activities that especially benefit trainees. Invited speakers were chosen based on excellence in research, topic, and willingness to engage trainees, as well as geographic diversity and gender balance. Participants will be chosen based on topic and demographics. Female and minority speakers have been invited, and those groups will be encouraged to apply as participants. The GRS pre-meeting will be organized by trainees for trainees to facilitate knowledge exchange and networking and provide them with a peer group as they transition into the larger meeting. Together, the GRC and GRS will thereby foster lasting interdisciplinary interactions and collaborations amongst NIH-funded and international vascular biologists to impart a strong and lasting impact on the field whose progression is now more timely and urgent than ever, with the growing knowledge of that vascular health is key not only for lifespan but also health span.