# Proteomics Core

> **NIH NIH U54** · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2024 · $34,450

## Abstract

PROJECT SUMMARY
The goal of the Protein-Metabolite Interactomics Core (PMIC) is to advance the understanding of protein-
protein and protein-metabolite interactions in relation to iron, heme, hematopoiesis and red cell biology. We
have developed a highly innovative approach to identify protein-metabolite interactions that regulate protein
function. This approach is termed Mass spectrometry Integrated with equilibrium dialysis for the Discovery of
Allostery Systematically or MIDAS, which utilizes purified proteins and a metabolite library to discover
interactions between any soluble protein of interest and components of a defined metabolite library. We have
validated our approach and shown that this platform, based on equilibrium dialysis, detects known and novel
metabolite-protein interactions with very high sensitivity, independent of specific assays of protein function.
This novel approach is able to discover unappreciated interactions that result in regulation of protein function.
The CIHD will utilize the expertise provided by the existing U0fU Proteomics Core to provide a unique
approach to discovery in the area of iron and heme homeostasis focused on combating nonmalignant
hematologic diseases.

## Key facts

- **NIH application ID:** 10899701
- **Project number:** 5U54DK110858-09
- **Recipient organization:** UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH
- **Principal Investigator:** Kevin George Hicks
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $34,450
- **Award type:** 5
- **Project period:** 2016-08-05 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10899701

## Citation

> US National Institutes of Health, RePORTER application 10899701, Proteomics Core (5U54DK110858-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10899701. Licensed CC0.

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