PROJECT SUMMARY/ABSTRACT Examining the complex drivers of health disparities requires a diverse research workforce trained in the transdisciplinary frameworks designed to address multiple domains and levels of influence and adept at employing health equity research methods. In 2020, the Icahn School of Medicine at Mount Sinai (ISMMS) created the Institute for Health Equity Research (IHER) to lead health disparities research across the institution and beyond. IHER faculty have extensive expertise in promoting inclusive excellence, providing training in health equity science methodology, and fostering academic-community partnerships with key stakeholders to ensure that community-informed disparities research is conducted and can lead to sustainable change. The overarching goal of the Catalyst Center Investigator Development Core (IDC) is to integrate faculty enhancement activities across the institution with the development and implementation of a pilot project program for early-stage investigators focused on health disparities research. The IDC will provide transdisciplinary educational programs and health equity research consultation services for investigators at all levels, and from all demographic and scientific backgrounds. The Catalyst Pilot Project Program will combine individualized mentoring; a curriculum of MH/HD research skills development; community engagement training; support for producing competitive future grant applications; and formal and informal opportunities for networking across the institution, and with local communities and policy makers. The IDC will achieve three aims: (1) Catalyze efforts to conduct health disparities research by faculty at all levels at Mount Sinai. We will provide methodology workshops and health equity topics seminars; sponsor a determinants of health journal club; provide opportunities to engage with community; and create a repository of resources. (2) Develop and implement a Pilot Project Program awarding 3 grants annually. Proposed pilot projects must: a) focus on our priority populations (i.e., racial/ethnic minorities, socioeconomically disadvantaged individuals, and/or sexual and gender minorities); b) address domains and levels of influence in the NIMHD framework; c) use principles of community engaged research; and d) aim to generate preliminary data for a mentored K or R01 submission. With support from a Catalyst faculty health equity mentor, Catalyst Scholars will develop an individual development plan (IDP), present their proposal to the Catalyst Community Board (CCB), participate in professional development activities (e.g., research project management, etc.), and work with the CCB on dissemination strategies. (3) Collaborate with the AC and CEDC to conduct a comprehensive evaluation of all IDC programs/activities, including faculty confidence and interest in conducting MH/HD research. The IDC’s cohesive program of educational offerings and resources will increase the capacity of faculty at...