Cold Spring Harbor Laboratory Conference GENE EXPRESSION AND SIGNALING IN THE IMMUNE SYSTEM April 16-20, 2024 ABSTRACT The proposed meeting on Gene Expression and Signaling in the Immune System, to be held in spring 2024, will focus on the most recent advances in this rapidly moving field. The meeting will be open, with attendance limited only by the facilities available to a maximum of ~425 participants. Oral presentations will be delivered by a combination of invited speakers and those selected from submitted abstracts. This ensures the participation of junior and senior leaders in the field and the presentation of the most exciting results emerging at the time of the meeting. A particular emphasis will be made to ensure that a substantial number of speakers will be advanced trainees or junior PIs. The oral presentations will be complemented by poster presentations in two sessions, also selected from submitted abstracts. The areas to be covered in the 2024 meeting include 1) Regulation of gene expression; 2) Differentiation; 3) Signaling at the membrane; 4) Intracellular signaling; 5) Intercellular communication; 6) Host:microbe interactions; 7) Immune Responses; and 8) Tissue-immune communications (immunophysiology). Rather than focusing on one particular type of immune cell or disease process, the meeting will highlight mechanistic approaches that aim to rigorously advance our knowledge of how the processes of signal transduction and gene regulation operate within the immune system at different scales. Ample opportunity is provided for the presentation of important, late- breaking findings. The meeting format also ensures and encourages highly productive discussions, particularly during meals and in poster sessions. The meeting will foster interactions among immunologists working in related areas, and provide a forum for the development of new ideas and approaches for current and future investigations of regulation of signaling and gene expression in the immune system.