# Cancer and Physical Sciences (CAPS) Research Program

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2023 · $63,337

## Abstract

ABSTRACT – CANCER AND PHYSICAL SCIENCES
The Cancer and Physical Sciences (CAPS) program capitalizes on the unique strengths and international
leadership of Northwestern University in nanotechnology and physical sciences. The program brings together
fundamental chemistry, nano-technology, imaging, and bioengineering groups to develop cancer-relevant
therapeutic and diagnostic agents using nanoscale materials and physical sciences approaches. The resulting
synergies have been leveraged by the Lurie Cancer Center (LCC) into the NCI-funded Center for Cancer
Nanotechnology Excellence (CCNE) and the NCI-funded Physical Sciences in Oncology Center (PSOC).
The CAPS Program received “Exceptional to Outstanding” merit at the last CCSG renewal application. Since
then the program has been further strengthened by enhancing the integration of engineering and physical
sciences investigators within the arena of cancer research, developing new strategies and technologies that
facilitate efficient interactions among program members and by accelerating translational efforts. Vadim
Backman, PhD, a bioengineer, is the Program Leader, and Gayle Woloschak, PhD, a biochemist and molecular
biologist, is the Program Co-Leader. This uniquely interdisciplinary program comprises 28 faculty members from
11 departments and 3 schools. Between 2013 and 2017 there have been 417 cancer-relevant publications from
the program members. Sixty-eight (16%) of these publications represent intra-programmatic collaborations, 87
(21%) represent inter-programmatic collaborations, and 207 (50%) represent external collaborative publications.
154 (37%) of the publications were in high impact (>9) journals. Current cancer-relevant funding is $12,212,040
(direct) in total peer-reviewed funding out of which $4,253,788 (direct) is from NCI. CAPS investigators focus
on (1) the elucidation of fundamental mechanisms and molecular pathways that control oncogenesis by physical
science methods, (2) the development of novel technologies for early cancer detection and (3) the discovery and
development of nanotechnology- and physical sciences based tumor targeting agents and therapeutic
modalities. Towards reaching these objectives, CAPS serves as a forum to link basic biological investigation
with practical applications from the fields of chemistry, physics, engineering and nanotechnology. It provides
webinars, symposia and financial awards to stimulate intra- and inter-programmatic collaborations on a broad
spectrum of translational projects. CAPS has facilitated the creation of innovative tools for the diagnosis,
detection, and treatment of cancer, including new imaging agents, a new technology for early cancer detection,
and novel therapeutic modalities. A number of these developments have advanced from basic engineering
research to clinical trials and clinical care. CAPS’ future plans are designed to further accelerate discovery and
translation within the LCC through faculty recruitment and bridge buil...

## Key facts

- **NIH application ID:** 10902193
- **Project number:** 4P30CA060553-29
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Vadim Backman
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2023
- **Award amount:** $63,337
- **Award type:** 4N
- **Project period:** 1997-08-15 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10902193

## Citation

> US National Institutes of Health, RePORTER application 10902193, Cancer and Physical Sciences (CAPS) Research Program (4P30CA060553-29). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10902193. Licensed CC0.

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