# Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring

> **NIH NIH F31** · VANDERBILT UNIVERSITY · 2024 · $34,295

## Abstract

PROJECT SUMMARY
Cardiovascular disease (CVD) is the leading cause of death globally. The root cause of CVD is a chronic
inflammatory disease of the arterial wall called atherosclerosis. A critical determinant of atherosclerosis is
macrophage inflammatory phenotype. Within atherosclerosis, anti-inflammatory pathways are dysfunctional,
which results in pro-inflammatory stimuli driving macrophage phenotype. We have identified Paired
immunoglobulin-like receptor B (PirB) as a novel inhibitor of macrophage-mediated inflammation by facilitating
apoptotic cell digestion and promoting mitochondrial function. The aims of this proposal will determine the
mechanisms by which PirB inhibits inflammation through phagosomal and mitochondrial signaling pathways. We
will use macrophages containing a lysosomal reporter to track phagosome maturation and cargo fate.
Additionally, we will dissect the molecular mechanism by which PirB regulates mitochondrial metabolic function
and signaling.

## Key facts

- **NIH application ID:** 10903465
- **Project number:** 1F31HL170766-01A1
- **Recipient organization:** VANDERBILT UNIVERSITY
- **Principal Investigator:** Matthew M Dungan
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $34,295
- **Award type:** 1
- **Project period:** 2024-05-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10903465

## Citation

> US National Institutes of Health, RePORTER application 10903465, Loss of myeloid Paired Immunoglobulin-like Receptor B promotes atherosclerosis through inhibition of autophagy and metabolic rewiring (1F31HL170766-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10903465. Licensed CC0.

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