# Bioresorbable zinc-based drug-eluting stents for pediatric cardiovascular applications

> **NIH NIH R01** · STATE UNIVERSITY NEW YORK STONY BROOK · 2024 · $733,929

## Abstract

Summary
This grant application is a renewal of an NIH-funded project in developing bioresorbable metallic stents in
treatment of heart disease. The goal of this study is to optimize a novel bioresorbable zinc-based drug-eluting
stents for pediatric cardiovascular applications and conduct comprehensive in vitro and in vivo testing to evaluate
their efficacy.
 Coarctation of the aorta is a common heart defect in children, causing narrowing of the aorta and resulting
in various symptoms. Traditional metallic drug-eluting stents are not suitable for pediatric patients due to their
interference with artery development. To address this, biodegradable drug-eluting stents (BDES) are being
explored. However, current materials have limitations in mechanical strength and degradation. To overcome this,
a new solution called biodegradable zinc-lithium-manganese (Zn-Li-Mn) stents with a drug-eluting coating (Z-
DES) has been developed. These stents offer mechanical strength, ductility, and stable biodegradation.
 The study aims to optimize the composition and configuration of Z-DES and evaluate its efficacy. In Aim
1, different Zn-Li-Mn alloys coated with PLLA and Sirolimus will be tested for mechanical properties and
biocompatibility. Aim 2 focuses on assessing Z-DES biodegradation and safety in rat abdominal aortas. Aim 3
aims to validate Z-DES in a large animal model with narrowed aortas. The success of this research could lead
to biodegradable pediatric stents that significantly improve patient outcomes and revolutionize cardiovascular
interventions in children.

## Key facts

- **NIH application ID:** 10904309
- **Project number:** 2R01HL140562-05
- **Recipient organization:** STATE UNIVERSITY NEW YORK STONY BROOK
- **Principal Investigator:** Ke Cheng
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $733,929
- **Award type:** 2
- **Project period:** 2018-06-01 → 2028-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904309

## Citation

> US National Institutes of Health, RePORTER application 10904309, Bioresorbable zinc-based drug-eluting stents for pediatric cardiovascular applications (2R01HL140562-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10904309. Licensed CC0.

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