# Bioinformatics and Modeling Core

> **NIH NIH P30** · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $156,162

## Abstract

Project Summary/Abstract – Bioinformatics and Modeling (BAM) Core
 Rheumatic diseases adversely affect the lives of millions of Americans. Yet, modern therapies remain
largely ineffective. Detailed knowledge of molecular disease mechanisms transforms medical management,
therapeutic approaches, diagnostics, and preventive strategies. Advances in bioinformatic and modeling
approaches have been, and will continue to be, tantamount to revealing rheumatic disease mechanisms.
 The goal of the Bioinformatics and Modeling (BAM) Core is to drive the quality control, analysis,
integration, modeling, and dissemination of large datasets to understand inflammatory and rheumatic diseases.
To this end, the BAM Core will continue to offer unique computational services and expertise to the P30 research
community, the Cincinnati Children’s Hospital Medical Center and University of Cincinnati research community,
and collaborators at other institutions. The BAM Core will implement innovative genomics and
immunophenotyping data management and analytic strategies to interrogate the datasets generated by users of
the Cincinnati Rheumatic Disease Resource Center. Publicly available software packages and newly developed,
innovative tools will be integrated, automated, applied and made available to the larger research community.
 The following Specific Aims will be spearheaded by The BAM Core in close collaboration with the
Research Base investigators and the Functional Genomics, Integrative Cell Phenotyping, and Tissue Repository
Cores:
Aim 1. To provide analytic expertise and informatic support for functional genomic experiments.
Aim 2. To support genotype-dependent analysis of functional genomic experiments.
Aim 3. To analyze high-dimensional flow cytometry data.
Aim 4. To facilitate the organization and deposition of genetic, genomic, and proteomic data.

## Key facts

- **NIH application ID:** 10904607
- **Project number:** 5P30AR070549-07
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** Matthew Tyson Weirauch
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $156,162
- **Award type:** 5
- **Project period:** 2016-08-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904607

## Citation

> US National Institutes of Health, RePORTER application 10904607, Bioinformatics and Modeling Core (5P30AR070549-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10904607. Licensed CC0.

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