# Functional Genomics Core

> **NIH NIH P30** · CINCINNATI CHILDRENS HOSP MED CTR · 2024 · $157,749

## Abstract

Project Summary/Abstract – Functional Genomics Core (FGC)
The Functional Genomics Core (FGC) will provide reagents, strategic, and technical expertise required for
efficient investigation of genetic variants likely to be mechanistically important in pediatric rheumatic and
inflammatory diseases. In doing so, the Functional Genomics Core will enhance research productivity and
efficiency by effectively reducing the “start-up” time required to implement these complex experimental systems,
thus reducing costs and effort required and allowing for better study designs and higher quality studies than if
investigators were to individually establish this technology. Further, this core will provide access to state-of-the-
art technology without requiring the users to become experts in these technologies. The Functional Genomics
Core will be a practical vehicle for the translation of basic advances to clinical disease applications and their very
important insights into pathogenesis. We will specifically provide consultation, collaboration, hands-on technical
expertise, and starter reagents to the research community to perform and analyze functional genomic
experiments (Aim1) and identify genotype-dependent gene regulatory mechanisms (Aim 2) to assess the
biological function of genetic variants associated with of autoimmune, autoinflammatory, and immune-related
rheumatic pediatric diseases. We expect the Functional Genomics Core to be a hub of innovation for the research
community, connecting scientists with the tools and expertise to take their research projects to the next level and
to accelerate the discovery of the molecular mechanisms that are responsible for the genetic associations
observed.

## Key facts

- **NIH application ID:** 10904608
- **Project number:** 5P30AR070549-07
- **Recipient organization:** CINCINNATI CHILDRENS HOSP MED CTR
- **Principal Investigator:** Leah Claire Kottyan
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $157,749
- **Award type:** 5
- **Project period:** 2016-08-01 → 2028-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904608

## Citation

> US National Institutes of Health, RePORTER application 10904608, Functional Genomics Core (5P30AR070549-07). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10904608. Licensed CC0.

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