# Core 1: Biospecimen/Pathology Core

> **NIH NIH P50** · UNIVERSITY OF WISCONSIN-MADISON · 2024 · $198,721

## Abstract

ABSTRACT – PATH CORE
The Biospecimen/Pathology Core (Path Core) of the Head Neck SPORE (HN SPORE) is dedicated to the
collection, processing, preservation, characterization, annotation, and distribution of biospecimens to enhance
translational research in head neck cancer (HNC). The theme of this core is to provide SPORE investigators with
a reliable, high-quality, and clinically diverse source of HNC biospecimens that are exhaustively annotated with
both clinical information as well as tumor specific bioinformatics. This will be achieved by enlarging the size and
variety of biospecimens available to investigators, creating innovative resources such as ‘on demand’ patient
derived xenografts, and augmenting biospecimen characterization including state of the art characterization of
the immune background of HNC biospecimens to facilitate Immuno-oncology. The mission of the Path Core is
to provide the type and quality of services that will enable HN SPORE investigators to easily initiate their
translational aims and generate reliable, clinically significant findings that will impact patient care. Successful
accomplishment of the translational aims for each of the HN SPORE projects is dependent on the Path Core.
The specific aims of the Path Core are strategically designed to produce a core service that will directly meet the
biospecimen needs of the HN SPORE projects and build a sustainable central organizing force for collaborative
translational HNC research in the future.
The Specific Aims for the Path Core are:
1. To collect, process, preserve and distribute HNC biospecimens.
2. To provide and maintain a centralized HN SPORE biospecimen bioinformatics database.
3. To provide a full range of expert services for biospecimen characterization.
4. To serve and support HN SPORE investigators and collaborate with other investigators in the
 HNC research community.

## Key facts

- **NIH application ID:** 10904792
- **Project number:** 5P50CA278595-08
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** David T Yang
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $198,721
- **Award type:** 5
- **Project period:** 2016-08-02 → 2027-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904792

## Citation

> US National Institutes of Health, RePORTER application 10904792, Core 1: Biospecimen/Pathology Core (5P50CA278595-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10904792. Licensed CC0.

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