# CSHL Cancer Center Support Grant

> **NIH NIH P30** · COLD SPRING HARBOR LABORATORY · 2024 · $4,495,455

## Abstract

OVERALL – ABSTRACT
The Cold Spring Harbor Laboratory (CSHL) Cancer Center is a preeminent institute for basic cancer research.
More than 50 years ago, strategically focused efforts investigated the genetics of human cancer, laying the
foundation for multiple breakthroughs today. As a result, researchers in the CSHL Cancer Center have made
discoveries about how tumors initiate and progress, and they have produced novel tools, approaches, and
cancer models that are used around the world.
Over the last five years, the leadership of the CSHL Cancer Center transitioned smoothly, with David Tuveson
assuming the role of Center Director. Tuveson substantially expanded the Cancer Center leadership team,
reorganized the Programs and Shared Resources, and added new research infrastructure to support new
initiatives and maintain the highly collaborative and integrated research in the Center. The CSHL Cancer Center
now has 43 full members, who are divided into three research programs: Cancer Genetics and Genomics;
Gene Regulation and Inheritance; and Cellular Communication in Cancer. The research in these Programs
is supported by 10 Shared Resources, which provide access to cutting-edge technologies and expertise.
This transition has propelled the Cancer Center’s research excellence. Broadly, the Cancer Center focuses on
three major themes: defining the basic molecular mechanisms underpinning cancer development and
progression; determining the features of neoplastic and stromal cellular heterogeneity that drive tumorigenesis;
and developing novel experimental and computational technologies to assist cancer diagnosis and therapy.
Center members published 408 cancer-relevant research papers during this funding cycle, with 41% in journals
with an impact factor greater than 10. Cancer Center members were recognized for their significant contributions
to science with 43 highly competitive national and international awards during this funding period. The Cancer
Center continues to be highly collaborative, with 27% of publications representing a collaboration between at
least two Center members. And finally, to support these efforts, members have obtained $11.8 million dollars in
cancer-relevant, peer-reviewed funding.
In the next funding period, the Cancer Center will continue to make foundational discoveries about cancer using
basic research. At the same time, the Cancer Center is committed to increasing links to cancer patients and
patient-derived models to facilitate an extension to human biology and clinical translation. Funds from the Cancer
Center Support Grant will support the Cancer Center Leadership, Administration, Education and Training, the
Developmental Funds that enhance innovative science, and the Shared Resources that provide essential
technologies to advance our cancer research.

## Key facts

- **NIH application ID:** 10904806
- **Project number:** 5P30CA045508-37
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** David A Tuveson
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $4,495,455
- **Award type:** 5
- **Project period:** 1997-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904806

## Citation

> US National Institutes of Health, RePORTER application 10904806, CSHL Cancer Center Support Grant (5P30CA045508-37). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10904806. Licensed CC0.

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