# Functional Genomics Shared Resource

> **NIH NIH P30** · COLD SPRING HARBOR LABORATORY · 2024 · $155,573

## Abstract

FUNCTIONAL GENOMICS SHARED RESOURCE – PROJECT SUMMARY/ABSTRACT
The Functional Genomics Shared Resource provides members of the Cold Spring Harbor Laboratory Cancer
Center with access to advanced RNAi and CRISPR screening technologies and services. A major focus of this
Shared Resource is to assist investigators with the design, implementation, and data analysis of multiplexed
RNAi/CRISPR screens in mammalian cells. The Shared Resource has generated unique shRNA and CRISPR
reagents that are not readily available elsewhere. These include a collection of verified domain-focused pooled
CRISPR libraries and shRNA libraries targeted against gene families known to play key roles in cancer. In
addition, the Shared Resource staff design and generate custom libraries based on Cancer Center member
requests, and they collaborate with members to develop and optimize novel screening approaches. Expert
training and assistance are provided to scientists at all stages of their functional genomics screening
experiments. It is the goal of the Functional Genomics Shared Resource to leverage its innovative approaches
to RNAi and genome editing to promote a deeper understanding of cancer pathways and dependencies, with
the potential for discovery of new therapeutic targets and generation of disease-relevant models for improving
human health. This Shared Resource is led by Faculty Head Christopher Vakoc, M.D., Ph.D., and Director
Kenneth Chang, Ph.D. Over the last grant period, 22 Cancer Center members (58% of the membership) used
the Functional Genomics Shared Resource, resulting in 32 publications.

## Key facts

- **NIH application ID:** 10904845
- **Project number:** 5P30CA045508-37
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** CHRISTOPHER VAKOC
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2024
- **Award amount:** $155,573
- **Award type:** 5
- **Project period:** 1997-08-01 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10904845

## Citation

> US National Institutes of Health, RePORTER application 10904845, Functional Genomics Shared Resource (5P30CA045508-37). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10904845. Licensed CC0.

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